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Kumar Verma, Amit
- In-silico Ligand and Structure Based Design of Hiv-1 Protease Inhibitors: Current Trends and Future Directions
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Authors
Affiliations
1 Department of Pharmacy, MJP Rohilkhand University, Bareilly 243006, Uttar Pradesh, IN
2 Department of Applied Chemistry, Faculty of Engineering and Technology, M. J. P. Rohilkhand University, Bareilly - 243006, Uttar Pradesh, IN
3 Department of Chemistry, B.S.A. Degree College, Mathura, Uttar Pradesh, IN
1 Department of Pharmacy, MJP Rohilkhand University, Bareilly 243006, Uttar Pradesh, IN
2 Department of Applied Chemistry, Faculty of Engineering and Technology, M. J. P. Rohilkhand University, Bareilly - 243006, Uttar Pradesh, IN
3 Department of Chemistry, B.S.A. Degree College, Mathura, Uttar Pradesh, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1477-1482Abstract
A study of the function of the protease inhibitor as well as of highly active antiretroviral therapy is involved in the present work. The paper focused on the cause of drug resistance and related phenomena, the HIV protease structure and its catalytic mechanism, the production of HIV inhibitors based on CADD, as well as ligand-based drug design using QSAR and computational binding energy technique, other computational modelling, optimization based on CORAL software. In order to shed light on the potential growth of the new drug for the treatment of HIV, the debate on the prediction of the desired biological activity and the structural relationship studies and study related to the structure-based drug design and the most potent drugs was reviewed.Keywords
In-silico Ligand, HIV-1 Protease Inhibitors, Highly Active Anti-Retroviral Therapy (HAART), Support Vector Machine (SVM).
References
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- Selection of Mode of Tandem Dragline Operations by Utilizing 3-dimensional Computer Graphics Balancing Diagram: A Case Study
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Authors
Affiliations
1 Department of Mining Engineering, IIT-BHU Varanasi 221005, Uttar Pradesh, IN
1 Department of Mining Engineering, IIT-BHU Varanasi 221005, Uttar Pradesh, IN
Source
Journal of Mines, Metals and Fuels, Vol 70, No 3 (2022), Pagination: 112-123Abstract
With the expansion of mines for higher rated outputs, the operation of a dragline in tandem has gained significance in the field. The tandem operation enhances capacity utilization of draglines which are highly capital-intensive equipment. To maximize the return on investment and improve the dragline’s performance, its mode of operation and influencing parameters must be understood and carefully analysed. The balancing diagram (a graphical representation of dragline cuts and spoil geometry) for the draglines operating in tandem is the most essential tool to deploy the dragline successfully. This task manually is normally both difficult and time-consuming and requires an analytical solution. This is best suited to the application of computer graphics methods. Therefore, a balancing diagram in a 3-dimensional graphics package has been developed to assist the mine planner in planning dragline operations. The purpose of this paper is to select the most appropriate mode of dragline operation, operating in tandem, and by analysing the two indices, i.e., rate of coal exposure and percentage rehandle. The analysis will be case studyoriented with practical mining considerations and comparatives indices being formulated for better understanding. In the present study, field data pertaining to the dragline operations have been collected from one of the prestigious mines of Northern Coalfields Limited, a subsidiary of Coal India Limited, and an attempt has been made to decide the mode of operation under the existing field conditions.Keywords
Balancing diagram, 3-dimensional balancing diagram, tandem operation, rate of coal exposure, rehandling percentage.References
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